Delivery of propellant soluble drug from a metered dose inhaler.
نویسندگان
چکیده
منابع مشابه
Delivery of propellant soluble drug from a metered dose inhaler.
The deposition of particulate suspensions delivered from a metered dose inhaler has been investigated extensively. The distribution of propellant, delivered from a metered dose inhaler, was studied by radiolabelling it with technetium-99m hexamethylpropyleneamine oxime. Andersen sampler measurements indicated that half of the dose was associated with particles in the size range 0.5-5 microns di...
متن کاملAsthma pressurised metered dose inhaler performance: propellant effect studies in delivery systems
BACKGROUND Current pressurised metered dose asthma inhaler (pMDI) propellants are not inert pharmacologically as were previous chlorofluorocarbons, have smooth muscle relaxant' partial pressure effects in the lungs and inhaled hydrofluoroalkane 134a (norflurane) has anaesthetic effects. Volumes of propellant gas per actuation have never been measured. METHODS In-vitro studies measured gas vol...
متن کاملBronchodilator delivery with metered-dose inhaler during mechanical ventilation
The delivery of bronchodilators with metered-dose inhaler (MDI) in mechanically ventilated patients has attracted considerable interest in recent years. This is because the use of the MDI has several advantages over the nebulizer, such as reduced cost, ease of administration, less personnel time, reliability of dosing and a lower risk of contamination. A spacer device is fundamental in order to...
متن کاملSalmeterol administration by metered-dose inhaler alone vs metered-dose inhaler plus valved holding chamber.
STUDY OBJECTIVE To determine whether a spacer device designed as a valved holding chamber with a flow signal increases the efficacy of the long-acting beta(2)-agonist, salmeterol, in patients who use incorrect technique with metered-dose inhaler (MDI) alone. DESIGN Double-blind, randomized, placebo-controlled study. SETTING University hospital outpatient rooms. PATIENTS Twenty adult outpa...
متن کاملPrinciples of metered-dose inhaler design.
The pressurized metered-dose inhaler (pMDI) was introduced to deliver asthma medications in a convenient and reliable multi-dose presentation. The key components of the pMDI device (propellants, formulation, metering valve, and actuator) all play roles in the formation of the spray, and in determining drug delivery to the lungs. Hence the opportunity exists to design a pMDI product by adjusting...
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ژورنال
عنوان ژورنال: Thorax
سال: 1991
ISSN: 0040-6376
DOI: 10.1136/thx.46.4.245